Product nameCholine glycerophosphate
Choline Alfoscerate
Chemical nameAlpha GPC
L-ALPHA-Glycerophosphoryl choline
Choline Glycerophosphate
(2S)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate
(2R)-2,3-dihydroxypropyl 2-(trimethylammonio)ethyl phosphate.
CAS Number28319-77-9
Mol. Mass257.22
Appearanceoff-white to white crystalline powder or colorless sticky liquid
SpecificationAlpha GPC 99% fine powder
Alpha GPC 85% liquid (Pharmaceutical Grade)
Alpha GPC 50% Granular powder
Alpha GPC 50% fine water-soluble powder

What is Alpha GPC?

Alpha GPC (also known as Choline alfoscerate) is L-Alpha Glycerylphosphorylcholine, it’s a natural choline compound from soy lecithin. Alpha GPC is very effective choline source and a potent nootropic supplement. Choline is a natural precursor to the Acetylcholine neurotransmitter. Acetylcholine is responsible in learning and memory as well as other important cognitive functions.

Alpha GPC has been experimentally demonstrated to reduce or reverse age-related structural changes in the frontal cortex and hippocampus and induced functional deficiencies of the cholinergic system. Research supports choline alfoscerate’s ability tosupport healthy brain function and the release of somatotrophin (hGH).

Alpha GPC has also been evaluated as a possible treatment for cognitive diseases like Alzheimer’s and has shown possible results in trials.

Alpha GPC Effects & Benefits

Alpha-GPC is primarily used for its cognitive enhancing properties, it has been shown to:

Increased learning and improved memory

Recovering brain following injury,coma and surgery

Alzheimer’s disease. Developing research suggests that taking 1200 mg of alpha-GPC per day significantly improves thinking skills in Alzheimer’s patients after 3 to 6 months of treatment.

Dementia. Giving 1000 mg of alpha-GPC per day as a shot might improve symptoms of vascular (multi-infarct) dementia including behavior, mood, and thinking skills. Researchers who did this study used a prescription-only form of alpha-GPC (Delecit) that is not available in the US.

Stroke and “mini-stroke” (transient ischemic attack, TIA). Stroke and TIA patients who receive alpha-GPC within 10 days after the stroke or TIA seem to have a better recovery. Early research suggests that people who get 1200 mg of alpha-GPC per day as a shot for 28 days, followed by 400 mg of alpha-GPC three times daily (1200 mg/day) by mouth for 6 months, recover more thinking skills and are better able to function.

Alpha GPC Dosage

A standard dosage of alpha-GPC is 300-600 mg, This dose is in accordance with the study using alpha-GPC to enhance power output (600 mg) and the two studies noting an increase in growth hormone secretion, and is likely a good dose to take for athletes.

For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg. It is unsure how lower doses would benefit cognition, but the 1,200 mg appears to be consistently associated with benefit.

Alpha GPC Side Effects & Safety

Alpha-GPC seems to be safe when used appropriately. It can cause side effects in some people including heartburn, headache, insomnia, dizziness, skin rash, and confusion.