Product namePalmitoylethanolamide (PEA)
Chemical nameN-(2-Hydroxyethyl)hexadecanamide
CAS Number544-31-0
Mol. Mass299.5
AppearanceWhite crystalline powder
Specification98% Palmitoylethanolamide (PEA)

What is Palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) is a food component known since 1957. Palmitoylethanolamide
(PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA
has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a
great variety of biological functions related to chronic pain and inflammation.

Development of Palmitoylethanolamide (PEA)

Since 1970, the anti-inflammatory and other immune-modulating properties of PEA have been shown in a number of placebo-controlled double-blind clinical trials on influenza and common cold.

Since 2008, PEA has been marketed as a food for special medical purposes in Italy and Spain, under the brand name Normast (Epitech Srl). Recently, a food-supplement named PeaPure was introduced (JP Russell Science Ltd.). In the USA, PEA is under evaluation as a nutraceutical for inflammatory bowel syndrome (proposed brand name Recoclix, CM&D Pharma Ltd.; Nestlé).

The birth date of Palmitoylethanolamide (PEA)

October 20, 1957, Kuehl et al to be the first to discover Palmitoylethanolamide (PEA). They published a seminal paper clarifying its structure and isolated an anti-inflammatory factor in crystalline form from soybean lecithin as well as from egg yolk.

Benefits of Palmitoylethanolamide (PEA)

Palmitoylethanolamide (PEA) has been shown to have anti-inflammatory, anti-nociceptive, neuroprotective, and anticonvulsant properties. And many sports nutrition supplements are starting to use it in formulas of joint supports, brain health, together with natural products like Cissus Quadrangularis, SAMe, MSM, glucosamine, chondroitin,etc

Chronic Pain

A Wikipedia article suggests PEA may be most effective in chronic pain disorders such as peripheral neuropathy, chronic regional pain syndrome (CRPS), sciatica, and nerve entrapment. A recent study suggests it could be helpful in Fibromyalgia.

Microglial Inhibitor

Dr. Younger included PEA in his long list of potential microglial inhibitors that might be of use in Chronic Fatigue Syndrome and Fibromyalgia. Microglial cells surround the neurons and are responsible for the elimination of pathogens that attack them.

Mast Cell Inhibitor

PEA appears to play a similar role with activated mast cells to what it does with over-activated neurons.

Studies suggest PEA can reduce mast cell migration and degranulation and can shift them from their activated to their resting states. Hesselink reports that over twenty studies have elucidated PEA’s mast-cell inhibiting effects.

Palmitoylethanolamide (PEA) Dosage

N-Palmitoylethanolamide is available as capsules of 400 mg
May use 30 mg/kg
First 2 months: 3 times 1 capsule daily
Next 2 months: In case of a positive result, 2 times 1 capsule daily, otherwise increase dose
After 4 months, you can consider the following:
Continue taking 2 times 1 capsule daily.
Reduce the ingestion to 1 times 1 capsule daily.
Stop the ingestion.

Side effect of Palmitoylethanolamide (PEA)

Till now, there was no any troublesome side-effects and easy to use to reduce pain, even together with other drugs.