Product nameVitamin B12
CAS Number68-19-9
Mol. Mass1355.37
Appearance Dark red crystals or crystalline powder
Specification: 98% Cyanocobalamin
Mol. Mass1344.38
Appearance Dark red crystals or crystalline powder
Specification: 98% Methylcobalamin
Mol. Mass1579.6
AppearanceDark red crystals or crystalline powder
Specification: 98% Adenosylcobalamin

What is Vitamin B12?

Vitamin B12 is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement and a prescription medication. Vitamin B12 exists in several forms and contains the mineral cobalt, so compounds with vitamin B12 activity are collectively called “cobalamins”. Methylcobalamin and 5-deoxyadenosylcobalamin are the forms of vitamin B12 that are active in human metabolism.

Benefits of Vitamin B12

It is needed to convert carbohydrates into glucose in the body, thus leading to energy production and a decrease in fatigue and lethargy in the body.

It helps in healthy regulation of the nervous system, reducing depression, stress, and brain shrinkage.

It helps maintain a healthy digestive system. Vitamin B12 also protects against heart disease by curbing and improving unhealthy cholesterol levels, protecting against stroke, and high blood pressure.

It is essential for healthy skin, hair, and nails. It helps in cell reproduction and constant renewal of the skin.

Vitamin B 12 helps protect against cancers including breast, colon, lung, and prostate cancer.
The European Journal of Clinical Nutrition concluded that the best way to address a B12 deficiency is the combination of the active forms MeCbl and AdCbl. Why?

  1. The active coenzyme forms of B12, methylcobalamin and adenosylcobalamin bypass usual mechanisms of absorption that rely on intrinsic factor.
  2. The combination is effective in addressing both the neurological and haematopoietic pathways.

Methylcobalamin is found in the cytosol of cells and interacts with an enzyme called methionine synthase; a critical enzyme involved in DNA synthesis and may be particularly useful for individuals with impaired methylation capacity.

Adenosylcobalamin is the mitochondrial form of the B12 vitamin found in cellular tissues and interacts with an enzyme called methylmalonyl CoA mutase, a metabolic enzyme, and may be useful for those with impaired energy production.

Methylcobalamin and adenosylcobalamin have different functions thus providing a total solution for those with B12 deficiency.

Vitamin B12 Dosage

Supplementation of vitamin B12 tends to be around 1,000mcg (1mg) of supplemental vitamin B12 to persons who are at risk for B12 insufficient or deficiency, mostly older individuals and vegans.

Side effect of Vitamin B12

Experiencing vitamin B 12 side effects can be rare; however, they do occur. Vitamin B 12 delivered through tablets or sublingual supplements will have fewer potential side effects than vitamin B 12 injections. The following side effects have been noted in both oral supplementation and injections of vitamin B12 unless otherwise noted. The most common side effects of vitamin B 12 supplementation include:

• Allergic reactions to preservatives in the preparation for the injection
• Mild diarrhea
• Anxiety
• Panic attacks
• Heart palpitations
• Insomnia
• Breathing problems
• Chest pain
• Rash and/or hives
• Itchy skin
• Heartburn
• Vomiting
• Back pain
• Rhinitis (stuffy nose)

In extremely rare cases, the following side effects have been noted:

• Congestive heart failure
• Pulmonary edema
• Peripheral vascular thrombosis (blood clots in the arms and legs)
• Folliculitis
• Inflammatory acne
• Anaphylaxis (most likely related to preservatives used in vitamin B 12 injections)

Because vitamin B 12 is a water soluble supplement, oral supplementation can often lead to bright yellow, strongly scented urine. This is a very common occurrence. Risks of side effects increase with dosage and method of delivery, with vitamin B12 injections having the highest incidence of reported severe side effects and oral supplementation having the lowest incidence of reported side effects, which were mostly mild and transitory.